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NCBI Bookshelf. Wolfram Ruf and Matthias Riewald. The cellular initiation of the coagulation protease cascade by tissue factor TF is the central pathway that initiates disseminated intravascular coagulation and contributes to lethality associated with septicemia. Following TF expression within the vasculature, inflammatory responses Pep boys Taby exaggerate the procoagulant effects by altering cell membrane properties and by destroying the inhibitory control of the TF-pathway. One consequence of the uncontrolled TF-initiated upstream protease cascade is autocrine cell signaling through protease activated receptors, capable bys supporting a self-perpetuating inflammatory response. Anticoagulant strategies that target both the prothrombotic as obys as the proinflammatory signaling effects of the coagulation protease cascade may result in effective attenuation of Free in Kinna language and mortality of sepsis.

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